CD3ε (intracellular) antibodies, human and mouse

CD3ε (intracellular) antibodies, human and mouse

Clone: REA975 | Dilution: 1:50
Clone REA975 recognizes an intracellular part of the CD3ε chain (activation epitope). CD3ε is a single-pass type I membrane protein, which is a part of the CD3 complex and a subunit of the TCR complex. The CD3 complex mediates signal transduction in several intracellular pathways and has a role in T cell activation and antigen recognition by binding the peptide/MHC antigen complex. CD3ε is expressed on all mature T lymphocytes, NKT cells, and during the development of thymocytes.
Additional information: Clone REA975 displays negligible binding to Fc receptors.

Alternative names

CD3e, CD3epsilon, T3E

Technical specifications

  • Antigen: CD3ε (intracellular)
  • Clone: REA975
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: CD3e, CD3epsilon, T3E
  • Entrez Gene ID: 916
  • Molecular mass of antigen [kDa]: 21
  • Distribution of antigen: T cells, NKT cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Vio515, Vio667
  • Selected references

    1. Gold, D. P. et al. (1987) Evolutionary relationship between the T3 chains of the T-cell receptor complex and the immunoglobulin supergene family. Proc. Natl. Acad. Sci. U.S.A. 84(21): 7649-7653
    2. Clevers, H. et al. (1988) Characterization and expression of the murine CD3-epsilon gene. Proc. Natl. Acad. Sci. U.S.A. 85(22): 8623-8627
    3. Soudais, C. et al. (1993) Independent mutations of the human CD3-epsilon gene resulting in a T cell receptor/CD3 complex immunodeficiency. Nat. Genet. 3(1): 77-81
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