CD37 antibodies, human

CD37 antibodies, human

Clone: REA366 | Dilution: 1:11
Clone REA366 recognizes the human CD37 antigen, a multi-pass membrane protein which is also known as tetraspanin-26 (Tspan-26). CD37 is a member of the transmembrane 4 superfamily of tetraspanin proteins, which consist of 4 potential membrane-spanning regions, 2 extracellular loops, and 2 short intracytoplasmic tails. Although most tetraspanins are ubiquitous proteins, CD37 expression is nearly exclusively limited to mature B cells and B cell–derived lymphoid malignancies. B cell early progenitors, T cells, natural killer cells, and myeloid cells exhibit only minimal amounts of membrane-associated CD37. In innate immunity, CD37 interacts with pattern recognition receptor dectin-1, stabilizing dectin-1 at the macrophage cell surface, and negatively regulating proinflammatory cytokine secretion following ligand recognition. Adaptive humoral immune responses are also perturbed by CD37 ablation. In cellular immunity, CD37 negatively regulates T cell proliferation. In APCs, CD37 associates with MHC class II at the cell surface and has been shown to negatively regulate antigen presentation. CD37 has recently attracted interest as a target for monoclonal antibodies with therapeutic potential in B cell malignancies.
Additional information: Clone REA366 displays negligible binding to Fc receptors.

Alternative names

GP52-40, TSPAN26

Technical specifications

  • Antigen: CD37
  • Clone: REA366
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: GP52-40, TSPAN26
  • Entrez Gene ID: 951
  • Molecular mass of antigen [kDa]: 32
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Schwartz-Albiez, R. et al. (1988) The B cell-associated CD37 antigen (gp40-52). Structure and subcellular expression of an extensively glycosylated glycoprotein. J. Immunol. 140(3): 905-914
    2. Classon, B. J. et al. (1989) The primary structure of the human leukocyte antigen CD37, a species homologue of the rat MRC OX-44 antigen. J. Exp. Med. 169(4): 1497-1502
    3. Gartlan, K. H. et al. (2013) Tetraspanin CD37 contributes to the initiation of cellular immunity by promoting dendritic cell migration. Eur. J. Immunol. 43(5): 1208-1219
Product options: 16
130-105-285

CD37-FITC, human

for 30
tests
(1)
USD 77.00
130-105-243

CD37-FITC, human

for 100
tests
(1)
USD 232.00
130-105-286

CD37-PE, human

for 30
tests
(1)
USD 97.00
130-105-244

CD37-PE, human

for 100
tests
(1)
USD 272.00
130-105-287

CD37-APC, human

for 30
tests
(1)
USD 124.00
130-105-245

CD37-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 126.00
for 100
tests
(1)
USD 300.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 132.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00

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