CD366 (TIM-3) antibodies, human

CD366 (TIM-3) antibodies, human

Clone: REA635 | Dilution: 1:11
Clone REA635 recognizes the human CD366 antigen, a single-pass type I membrane protein, which is also known as T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). CD366 is expressed on activated T cells, especially Tʜ1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit Tʜ1-mediated immune responses and regulates Tʜ1 and Tʜ17 cytokine secretion. The interaction of CD366 and its ligand galectin-9 induces apoptosis of Tʜ1 cells.
Additional information: Clone REA635 displays negligible binding to Fc receptors.

Alternative names

HAVcr-2, TIMD-3

Technical specifications

  • Antigen: CD366 (TIM-3)
  • Clone: REA635
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: HAVcr-2, TIMD-3
  • Entrez Gene ID: 84868
  • Molecular mass of antigen [kDa]: 31
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: dendritic cells, macrophages, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, Biotin
  • Selected references

    1. Monney, L. et al. (2002) Tʜ1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541
    2. Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6(12): 1245-1252
    3. Hastings, W. D. et al. (2009)
      TIM-3 is expressed on activated human CD4
      T cells and regulates Tʜ1 and Tʜ17 cytokines.
      Eur. J. Immunol. 39(9): 2492-2501
Product options: 4
for 30
USD 138.00
for 100
USD 345.00
for 30
USD 77.00
for 100
USD 232.00

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