CD307a (FcRL1) antibodies, human

CD307a (FcRL1) antibodies, human

Clone: REA440 | Dilution: 1:11
Clone REA440 recognizes the human CD307a antigen, a single-pass type I membrane protein which is also known as Fc receptor-like protein 1 (FcRL1) or immune receptor translocation-associated protein 5 (IRTA5). CD307a is preferentially expressed on naive and memory B cells. It has two ITAM-like motifs, an acidic glutamic acid residue in its transmembrane region, and three extracellular immunoglobulin-like domains. Ligands for CD307a have not been identified, but the presence of ITAM-like motifs suggests its potential for B cell–activation.
Additional information: Clone REA440 displays negligible binding to Fc receptors.

Alternative names

FcRL1, FcRH1, IFGP1, IRTA5

Technical specifications

  • Antigen: CD307a (FcRL1)
  • Clone: REA440
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: FcRL1, FcRH1, IFGP1, IRTA5
  • Entrez Gene ID: 115350
  • Molecular mass of antigen [kDa]: 45
  • Distribution of antigen: B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Leu, C. M. et al. (2005) FcRH1: an activation coreceptor on human B cells. Blood 105(3): 1121-1126
    2. Polson, A. G. et al. (2006) Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Int. Immunol. 18(9): 1363-1373
    3. Davis, R. S. et al. (2001) Identification of a family of Fc receptor homologs with preferential B cell expression. Proc. Natl. Acad. Sci. U.S.A. 98(17): 9772-9777
Product options: 8
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USD 288.00
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USD 142.00
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USD 305.00
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USD 87.00
for 100
tests
(1)
USD 232.00

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