CD300e (IREM-2) antibodies, human

CD300e (IREM-2) antibodies, human

Clone: UP-H2 | Dilution: 1:11
The monoclonal antibody UP-H2 reacts with human CD300e, also known as IREM-2, LMIR6, or CMRF35-A5. This 34 kDa activating receptor of the immunglobulin superfamily is expressed on mature myeloid dendritic cells and monocytes and is down-regulated on immature dendritic cells. CD300e interacts with DAP-12, which mediates acivating signals. It is reported that the alloreactive response of naive T cells is enhanced by IREM-2 activation of mDCs.

Alternative names

CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6

Technical specifications

  • Antigen: CD300e (IREM-2)
  • Clone: UP-H2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CD300LE, CLM-2, CMRF35-A5, IREM-2, PIgR-2, LMIR6
  • Distribution of antigen: monocytes, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, VioBlue, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Aguilar, H. et al. (2004) Molecular characterization of a novel immune receptor restricted to the monocytic lineage. J. Immunol. 173: 6703-6711
    2. Brckalo, T. et al. (2010) Functional analysis of the CD300e receptor in human monocytes and myeloid dendritic cells. Eur. J. Immunol. 40(3): 722-732
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USD 232.00

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