CD295 (LEPR) antibodies, human

CD295 (LEPR) antibodies, human

Clone: REA361 | Dilution: 1:11
Clone REA361 recognizes the human CD295 antigen, a single-pass type I membrane protein which is also known as leptin receptor (LEPR). CD295 is a member of the type I cytokine receptor family which acts through Janus kinases and signal transducers and activators of transcription. It is predominantly expressed in the central nervous system and in multiple tissues, including the choroid plexus, lung, kidney, and primitive hematopoietic cell populations. CD295 is the receptor for leptin, a peptide hormone which is secreted by the adipose tissue at levels roughly proportional to fat content. Leptin communicates the repletion of peripheral energy stores to the brain, suppressing feeding and permitting/promoting energy expenditure via a variety of neuroendocrine and autonomic mechanisms.
Additional information: Clone REA361 displays negligible binding to Fc receptors.

Alternative names

LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)

Technical specifications

  • Antigen: CD295 (LEPR)
  • Clone: REA361
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: LEPR, LEP-R, LEPRD, OB-R, OBR, HuB219 (B219)
  • Entrez Gene ID: 3953
  • Molecular mass of antigen [kDa]: 130
  • Distribution of antigen: brain, lung, kidney, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Tartaglia, L. A. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83(7): 1263-1271
    2. Cioffi, J. A. et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat. Med. 2(5): 585-589
    3. Villanueva, E. C. et al. (2008) Leptin receptor signaling and the regulation of mammalian physiology. Int. J. Obes. (Lond.) 32(7): 8-12
Product options: 12
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 345.00
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00

Related products

2 products available