CD270 (HVEM) antibodies, human

CD270 (HVEM) antibodies, human

Clone: REA247 | Dilution: 1:11
Clone REA247 recognizes CD270, which is also known as HVEM and derives its name based on the ability of types 1 and 2 herpesvirus gD to bind to it for entry into the cell. CD270 is a type 1 transmembrane protein with a predicted molecular weight of 30 kDa and is a member of the TNFR superfamily. CD270 transmits both activating and inhibitory signals for, e.g., interaction with receptors such as BTLA or CD160 attenuates TCR-mediated signaling, whereas interaction with receptor LIGHT allows co-stimulation of T and B cells. Expression of CD270 is widely distributed and is found on hematopoietic cells such as dendritic cells, Tregs, monocytes, neutrophils, NK cells, B cells, and T cells, as well as on non-hematopoietic cells.
Additional information: Clone REA247 displays negligible binding to Fc receptors.

Alternative names

TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2

Technical specifications

  • Antigen: CD270 (HVEM)
  • Clone: REA247
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF14, ATAR, HVEA, HVEM, LIGHTR, TR2
  • Entrez Gene ID: 8764
  • Molecular mass of antigen [kDa]: 26
  • Distribution of antigen: T cells, B cells, dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, APC-Vio770, Biotin, FITC, PE, APC
  • Selected references

    1. Ware, C. F. et al. (2009) Targeting the LIGHT-HVEM pathway. Adv. Exp. Med. Biol. 647: 146-155
    2. Pasero, C. et al. (2012) The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy. Curr. Opin. Pharmacol. 12(4): 478-485
Product options: 12
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USD 232.00

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