CD27 antibodies, human and mouse

CD27 antibodies, human and mouse

Clone: REA499 | Dilution: 1:50
Clone REA499 recognizes the human and mouse CD27 antigen, a single-pass type I membrane protein, also known as tumor necrosis factor receptor superfamily member 7 (TNFRSF7). CD27 is a member of the nerve growth factor receptor family and is exclusively expressed on cells of the lymphoid lineage, mostly in an activation-specific manner, and all enhance T cell receptor (TCR)–induced T cell expansion. CD27 and its ligand, CD70, have been defined at the protein, cDNA, and genomic level in both human and mouse. It is found on natural killer (NK), T, and B cell populations. In human and mice, the majority of CD4
+
and CD8
+
naive peripheral T cells express CD27 and expression is up-regulated upon TCR stimulation. Loss of CD27 expression is irreversible and seems to represent terminal effector T cell differentiation. In humans, naive B cells lack CD27 but antigen receptor stimulation induces expression. CD27
+
B cells display all the functional and phenotypic characteristics of memory cells.
Additional information: Clone REA499 displays negligible binding to Fc receptors.

Alternative names

S152, TNFRSF7, Tp55, T14

Technical specifications

  • Antigen: CD27
  • Clone: REA499
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: S152, TNFRSF7, Tp55, T14
  • Entrez Gene ID: 939, 21940
  • Molecular mass of antigen [kDa]: 27, 26
  • Distribution of antigen: B cells, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin, VioBlue, PerCP-Vio700, VioBright 515, PE-Vio615
  • Selected references

    1. Camerini, D. et al. (1991) The T cell activation antigen CD27 is a member of the nerve growth factor/tumor necrosis factor receptor gene family. J. Immunol. 147(9): 3165-3169
    2. Prasad, K. V. et al. (1997) CD27, a member of the tumor necrosis factor receptor family, induces apoptosis and binds to Siva, a proapoptotic protein. Proc. Natl. Acad. Sci. U.S.A. 94(12): 6346-6351
    3. Gravestein, L. A. et al. (1993) Cloning and expression of murine CD27: comparison with 4-1BB, another lymphocyte-specific member of the nerve growth factor receptor family. Eur. J. Immunol. 23(4): 943-950
  • Customer reports and application notes

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USD 300.00

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