CD252 (OX40L) antibodies, mouse

CD252 (OX40L) antibodies, mouse

Clone: REA960 | Dilution: 1:50
Clone REA960 recognizes the mouse CD252 antigen, also known as OX40L, a ligand of the OX40 receptor belonging to the TNF superfamily. Expression of CD252 can be induced on B cells, dendritic cells, macrophages, mast cells, NK cells, endothelial cells, and smooth muscle cells. Expression of the cognate receptor OX40, is found on activated CD4 cells, CD8 cells, regulatory T cells, NKT cells, NK cells, and neutrophils, but the function of OX40 signaling is extensively studied only in T cells. CD252–OX40 interaction promotes the proliferation and surival of effector T cells, modulates cytokine production, suppresses the activity of natural regulatory T cells (nTreg) and inhibits the generation of inducible Treg cells.
Additional information: Clone REA960 displays negligible binding to Fc receptors.

Alternative names

OX40L, TNFSF4, Ath-1, Ath1, CD134L, Txgp1, Txgp1l, gp34

Technical specifications

  • Antigen: CD252 (OX40L)
  • Clone: REA960
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: OX40L, TNFSF4, Ath-1, Ath1, CD134L, Txgp1, Txgp1l, gp34
  • Entrez Gene ID: 22164
  • Molecular mass of antigen [kDa]: 22
  • Distribution of antigen: heart, spleen, B cells, dendritic cells, endothelial cells, mast cells, monocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, Biotin, FITC
  • Selected references

    1. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
    2. Croft, M. et al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1): 173-191
    3. Ishii, N. et al. (2010) OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology. Adv. Immunol. 105: 63-98
Product options: 8
30 µg in 200 µL (1)
USD 45.00
30 µg in 200 µL (1)
USD 55.00
150 µg in 1 mL (1)
USD 190.00
30 µg in 200 µL (1)
USD 80.00
150 µg in 1 mL (1)
USD 315.00
30 µg in 200 µL (1)
USD 136.00
150 µg in 1 mL (1)
USD 395.00
30 µg in 200 µL (1)
USD 55.00

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