Clone REA832 recognizes the human CD24 antigen, which is also known as heat-stable antigen (HSA). CD24 is a glycosylphosphatidylinositol (GPI)–linked sialoglycoprotein that is anchored to the plasma membrane. CD24 has been identified to be a negative marker for breast cancer stem cells and a positive marker for ovarian or pancreatic cancer stem cells. The CD24 antibody can be used, for example, to differentiate CD44+
breast cancer stem cells from CD24+
expressing cells from a primary tumor sample. Furthermore, CD24 is found on follicular dendritic cells and different epithelial and hematopoietic cell types.