CD221 (IGF-1R) antibodies, human

CD221 (IGF-1R) antibodies, human

Clone: REA271 | Dilution: 1:11
Clone REA271 recognizes human CD221 (IGF-1R), a widely expressed cell-surface glycoprotein composed of two α subunits and two β subunits. Both the α and β subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds to form a functional transmembrane αβ chain. The α chains are located extracellularly, while the β subunits span the membrane and are responsible for intracellular signal transduction upon ligand stimulation. IGF-1R is activated by binding of its ligands insulin-like growth factor 1 (IGF-1), IGF-2, as well as insulin to the extracellular α subunits. Ligand binding leads to autophosphorylation of tyrosine residues in the cytoplasmic regions of the receptor β subunits and subsequent recruitment and phosphorylation of insulin receptor substrate (IRS) proteins. This finally results in activation of the PI3K/Akt and MAPK pathways, which mediate cell proliferation and survival. Many tumors and transformed cells exhibit altered IGF-1R expression.
Additional information: Clone REA271 displays negligible binding to Fc receptors.

Alternative names

IGF1R, IGFIR, IGFR, JTK13

Technical specifications

  • Antigen: CD221 (IGF-1R)
  • Clone: REA271
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IGF1R, IGFIR, IGFR, JTK13
  • Entrez Gene ID: 3480
  • Molecular mass of antigen [kDa]: 151
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Biotin
  • Selected references

    1. Chitnis, M. M. et al. (2008) The type 1 insulin-like growth factor receptor pathway. Clin. Cancer Res. 14(20): 6364-6370
Product options: 6
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00

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