CD209 (DC-SIGN) antibodies, human

CD209 (DC-SIGN) antibodies, human

Clone: REA617 | Dilution: 1:11
Clone REA617 recognizes the CD209 antigen, also known as dendritic cell specific ICAM-3 grabbing non-integrin (DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, as well as on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14
+
cells with a DC-like phenotype. DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast. HIV-1 uses this feature of DC-SIGN for efficient intrans infection of CD4
+
T cells.
Additional information: Clone REA617 displays negligible binding to Fc receptors.

Alternative names

DC-SIGN, DC-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1

Technical specifications

  • Antigen: CD209 (DC-SIGN)
  • Clone: REA617
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: DC-SIGN, DC-type lectin domain family 4 member L, Dendritic cell-specific ICAM-3-grabbing non-integrin 1, DC-SIGN1
  • Entrez Gene ID: 30835
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, skin, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, VioBlue, PE-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. Geijtenbeek, T. B. et al. (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100: 575-585
    2. Geijtenbeek, T. B. et al. (2002) Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. J. Biol. Chem. 277(13): 11314-11320
    3. Koppel, E. A. et al. (2005) Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. Cell. Microbiol. 7: 157-165
Product options: 8
for 30
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(1)
USD 126.00
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tests
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USD 300.00
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USD 142.00
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tests
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USD 305.00
for 30
tests
(1)
USD 132.00
for 100
tests
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USD 315.00
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tests
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USD 77.00
for 100
tests
(1)
USD 232.00