CD209 (DC-SIGN) antibodies, human

CD209 (DC-SIGN) antibodies, human

Clone: DCN47.5 | Dilution: 1:11
Clone DCN47.5 recognizes CD209 (Dendritic Cell Specific ICAM-3 Grabbing Non-integrin, DC-SIGN), a type II c-type lectin expressed in dermal and mucous tissue, lymphoid tissue such as tonsil, lymph node, spleen, and on monocyte-derived DCs (MoDCs). It is not expressed on DC subsets in peripheral blood, except for a subpopulation of CD14
+
cells with a DC-like phenotype.
DC-SIGN acts as an adhesion receptor to facilitate interactions between DCs and T cells or DCs and endothelial cells. In addition, it serves as an antigen receptor mediating internalization of ligands for antigen presentation, binding virus such as HIV, HCMV, or Ebola as well as parasites, bacteria, or yeast.
HIV-1 uses this feature of DC-SIGN for efficient in
-trans
infection of CD4
+
T cells.

Alternative names

CDSIGN, CLEC4L, DC-SIGN

Technical specifications

  • Antigen: CD209 (DC-SIGN)
  • Clone: DCN47.5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CDSIGN, CLEC4L, DC-SIGN
  • Entrez Gene ID: 30835
  • Molecular mass of antigen [kDa]: 46
  • Distribution of antigen: dendritic cells, endothelial cells, macrophages, skin, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBlue, PE-Vio770, APC-Vio770, Biotin, pure, FITC, PE, APC
  • Selected references

    1. Koppel, E. A. et al. (2005) Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation. Cell. Microbiol. 7: 157-165
    2. Geijtenbeek, T. B. et al. (2000) Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 100: 575-585
Product options: 14
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 232.00
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 130.00
for 100
tests
(1)
USD 300.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 132.00
for 100
tests
(1)
USD 315.00
for 100
tests
(1)
USD 232.00
100 µg in 1 mL
USD 130.00

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