CD207 (Langerin) antibodies, human

CD207 (Langerin) antibodies, human

Clone: MB22-9F5 | Dilution: 1:11
Langerin (CD207 antigen), a 40 kDa, glycosylated type II transmembrane C-type lectin receptor, is the standard marker for human and murine Langerhans cells (LCs).
LCs are a subset of dendritic cells (DCs) cells that reside in epithelia; the best studied example of these antigen-presenting cells are LCs of the epidermis.
CD207 is directly involved in antigen capture as well as endocytosis and induces the formation of typical Birbeck granules in immature DCs.

Alternative names

CLEC4K, Langerin

Technical specifications

  • Antigen: CD207 (Langerin)
  • Clone: MB22-9F5
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: CLEC4K, Langerin
  • Entrez Gene ID: 50489
  • Molecular mass of antigen [kDa]: 37
  • Distribution of antigen: dendritic cells, Langerhans cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, VioBlue, PE-Vio770, APC-Vio770, Biotin, FITC
  • Selected references

    1. Stoitzner, P. et al. (2010) Isolation of skin dendritic cells from mouse and man. Methods Mol. Biol. 595: 235-248
    2. Geissmann, F. et al. (1998) Transforming growth factor β1, in the presence of granulocyte/macrophage colony-stimulating factor and interleukin 4, induces differentiation of human peripheral blood monocytes into dendritic Langerhans cells J. Exp. Med. 187(6): 961-996
    3. Rozis, G. et al. (2008) Human Langerhans cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands Immunology 124(3): 329-338
    4. Valladeau, J. et al. (2000) Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity 12(1): 71-81
    5. Romani, N. et al. (2010) Langerhans cells and more: langerin-expressing dendritic cell subsets in the skin. Immunol. Rev. 234(1): 120-141
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