CD2 antibodies – functional grade, human

CD2 antibodies – functional grade, human

Clone: LT2
The CD2 antibody recognizes the human CD2 antigen, a 50 kDa single-chain transmembrane glycoprotein also known as LFA-2 or receptor for sheep erythrocytes. It reacts with 80–90% of peripheral blood lymphocytes and more than 95% of thymocytes. The antibody recognizes all T cells and a subset of natural killer (NK) cells. Activation and proliferation of T cells can be induced by interaction of the T cell receptor with peptide-MHC complexes expressed on the surface of antigen-presenting cells (APCs). The T cell receives a signal transduced through the CD3 complex. Cytokines or other costimulatory signals are required in addition. Activated T cells can be used for any downstream processes, such as cytokine analysis or immunoprecipitation.

Applications

The CD2-Biotin – functional grade antibody is suited for functional assays, for example, activation and expansion of T cells together with CD3-Biotin – functional grade antibody, CD28-Biotin – functional grade antibody, and Anti-Biotin MACSiBead™ Particles, cell culture grade.

Alternative names

LFA-2, SRBC-R, T11, SRBC

Technical specifications

  • Antigen: CD2
  • Clone: LT2
  • Isotype: mouse IgG2b
  • Alternative names of antigen: LFA-2, SRBC-R, T11, SRBC
  • Entrez Gene ID: 914
  • Molecular mass of antigen [kDa]: 37
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    squirrel monkey (
    Saimiri sciureus
    )
  • Distribution of antigen: B cells, lymphocytes, macrophages, mast cells, NK cells, T cells, thymocytes
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: Biotin
Product options: 1
100 µg in 1 mL
USD 255.00

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