CD196 (CCR6) antibodies, mouse

CD196 (CCR6) antibodies, mouse

Clone: REA277 | Dilution: 1:10
Clone REA277 recognizes the CD196 antigen, a G protein–linked chemokine receptor also known as C-C chemokine receptor type 6 (CCR6). CD196 is preferentially expressed by B cells, immature dendritic cells, and subsets of T cells. The ligand of CD196 is macrophage inflammatory protein 3 alpha (MIP-3α) and binding subsequently transduces a signal by increasing the intracellular calcium ions level. CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Targeting CD196 or its ligand may be a promising therapeutic strategy to alleviate atherosclerosis.
Additional information: Clone REA277 displays negligible binding to Fc receptors.

Alternative names

CCR6, CC-CKR-6, CCR-6, CMKBR6, KY411

Technical specifications

  • Antigen: CD196 (CCR6)
  • Clone: REA277
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: CCR6, CC-CKR-6, CCR-6, CMKBR6, KY411
  • Entrez Gene ID: 12458
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: B cells, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770
  • Selected references

    1. Greaves, D. R. et al. (1997) CCR6, a CC chemokine receptor that interacts with macrophage inflammatory protein 3 alpha and is highly expressed in human dendritic cells. J. Exp. Med. 186(6): 837-844
    2. Baba, M. et al. (1997) Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC. J. Biol. Chem. 272(23): 14893-14898
    3. Varona, R. et al. (1998) Molecular cloning, functional characterization and mRNA expression analysis of the murine chemokine receptor CCR6 and its specific ligand MIP-3alpha. FEBS Lett. 440(1-2): 188-194
Product options: 8
9 µg in 300 µL (1)
USD 35.00
30 µg in 1 mL (1)
USD 56.00
9 µg in 300 µL (1)
USD 51.00
30 µg in 1 mL (1)
USD 80.00
9 µg in 300 µL (1)
USD 47.00
30 µg in 1 mL (1)
USD 136.00
9 µg in 300 µL (1)
USD 52.00
30 µg in 1 mL (1)
USD 136.00

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