CD186 (CXCR6) antibodies, human

CD186 (CXCR6) antibodies, human

Clone: REA458 | Dilution: 1:50
Clone REA458 recognizes the human CD186 antigen, a multi-pass membrane protein which is also known as C-X-C chemokine receptor type 6 (CXCR6), STRL33, or bonzo. CD186 is expressed on a subset of type 1 polarized peripheral blood CD4
+
and CD8
+
T cells, γδ T cells, natural killer T cells, natural killer cells, monocytes, and B cells. It is induced in activated peripheral blood lymphocytes. The ligand of CD186 is the chemokine CXCL16. CD186 is used as a coreceptor by SIVs and by strains of HIV-2 and m-tropic HIV-1.
Additional information: Clone REA458 displays negligible binding to Fc receptors.

Alternative names

CXCR6, BONZO, STRL33, TYMSTR

Technical specifications

  • Antigen: CD186 (CXCR6)
  • Clone: REA458
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CXCR6, BONZO, STRL33, TYMSTR
  • Entrez Gene ID: 10663
  • Molecular mass of antigen [kDa]: 39
  • Distribution of antigen: T cells, NKT cells, NK cells, monocytes, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Wehr, A. et al. (2013) Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis. J. Immunol. 190(10): 5226-5236
    2. Deng, H. K. et al. (1997) Expression cloning of new receptors used by simian and human immunodeficiency viruses. Nature 388(6639): 296-300
    3. Deng, L. et al. (2010) CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer. Biochim. Biophys. Acta 1806(1): 42-49
Product options: 2
for 30
tests
(1)
USD 102.00
for 100
tests
(1)
USD 278.00

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