CD184 (CXCR4) antibodies, human

CD184 (CXCR4) antibodies, human

Clone: 12G5 | Dilution: 1:50
The monoclonal antibody 12G5 recognizes human CD184, also known as CXCR4 or fusin, a 45 kDa seven transmembrane G-protein–linked chemokine receptor for SDF-1. CXCR4 is ubiquitously expressed on blood and tissue cells. It mediates chemotaxis in mature and progenitor blood cells and is important for B lympho- and myelopoiesis and cardiogenesis. It is reported to block CD4-independent HIV-2 infection and CD4-dependent infection by some T cell tropic isolates of HIV-1.

Alternative names

CXCR4, LAP-3, LCR1, LESTR, NPY3R, WHIM, WHIMS, Fusin

Technical specifications

  • Antigen: CD184 (CXCR4)
  • Clone: 12G5
  • Isotype: mouse IgG2aκ
  • Isotype control: Mouse IgG2a – isotype control antibodies
  • Alternative names of antigen: CXCR4, LAP-3, LCR1, LESTR, NPY3R, WHIM, WHIMS, Fusin
  • Entrez Gene ID: 7852
  • Molecular mass of antigen [kDa]: 40
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
  • Distribution of antigen: B cells, brain, dendritic cells, endothelial cells, epithelial cells, granulocytes, heart, hematopoietic stem cells, kidney, leukocytes, liver, lung, lymphocytes, megakaryocytes, mesenchymal stem cells, monocytes, myeloid cells, neurons, pancreas, placenta, platelets, skeletal muscle, spleen, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC
  • Selected references

    1. Ichiyama, K. et al. (2003) A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. U.S.A. 100: 4185-4190
    2. McKnight, A. et al. (1997) Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent. J. Virol. 71(2): 1692-1696
    3. Berger, E. A. et al. (1999) Chemokine receptors as HIV-1 coreceptors: roles in viral entry, tropism, and disease. Annu. Rev. Immunol. 17: 657-700
    4. Loetscher, P. et al. (2000) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv. Immunol. 74: 127-180
Product options: 4
for 30
tests
(1)
USD 102.00
for 100
tests
(1)
USD 274.00
for 30
tests
(1)
USD 122.00
for 100
tests
(1)
USD 288.00

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