CD18 antibodies, mouse

CD18 antibodies, mouse

Clone: REA1226 | Dilution: 1:50
Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. It is expressed on all leukocytes with NK and T cells showing higher density of surface expression. The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation.
Additional information: Clone REA1226 displays negligible binding to Fc receptors.

Alternative names

Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr

Technical specifications

  • Antigen: CD18
  • Clone: REA1226
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Integrin beta-2, ITGB2, LTbetaR, TNF-R-III, Ltbr, TNFR-RP, TNFR2-RP, TNFCR, Tnfbr
  • Entrez Gene ID: 17000
  • Molecular mass of antigen [kDa]: 42
  • Distribution of antigen: leukocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC, PE-Vio615, PE-Vio770, Biotin, PE
  • Selected references

    1. Wilson, R. W. et al. (1993) Gene targeting yields a CD18-mutant mouse for study of inflammation. J. Immunol. 151: 1571-1578
    2. Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. Biosci. Rep. 32(3): 241-269
    3. Jakus, Z. et al. (2007) Immunoreceptor-like signaling by β 2 and β 3 integrins. Trends Cell Biol. 17(10): 493-501
Product options: 5
130-124-119

CD18-PE, mouse

30 µg in 200 µL (1)
USD 55.00
130-124-120

CD18-APC, mouse

30 µg in 200 µL (1)
USD 80.00
30 µg in 200 µL (1)
USD 135.00
30 µg in 200 µL (1)
USD 135.00
30 µg in 200 µL (1)
USD 55.00