CD172b (SIRPβ) antibodies, human

CD172b (SIRPβ) antibodies, human

Clone: REA1170 | Dilution: 1:50
Clone REA1170 recognizes the human CD172b antigen, a single-pass type I membrane protein also known as signal-regulatory protein beta (SIRPβ). Signal regulatory proteins (SIRPs) are a family of transmembrane receptor-like signaling proteins that are abundantly expressed in hematopoietic cells, including granulocytes, monocytes, dendritic cells, and lymphocytes. In addition, SIRPs are expressed in neuronal cells and certain types of cancer cells. SIRPs can be divided into two subfamilies, CD172a and CD172b, based on the putative structures of their C-terminal intracellular domains which distinguish them as either activating (CD172b) or inhibitory (CD172a) isoforms. CD172b is expressed on peripheral blood monocytes, dendritic cells, and granulocytes.
Additional information: Clone REA1170 displays negligible binding to Fc receptors.

Alternative names

Signal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B

Technical specifications

  • Antigen: CD172b (SIRPβ)
  • Clone: REA1170
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Signal-regulatory protein β-1 (SIRP-β-1), SIRP-BETA-1, CD172 antigen-like family member B
  • Entrez Gene ID: 10326
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: dendritic cells, granulocytes, lymphocytes, monocytes, neural stem cells, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, VioBright 515, Biotin
  • Selected references

    1. Kharitonenkov, A. et al. (1997) A family of proteins that inhibit signalling through tyrosine kinase receptors. Nature 386(6621): 181-186
    2. Dietrich, J. et al. (2000) Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164(1): 9-12
    3. Liu, Y. et al. (2005) SIRPbeta1 is expressed as a disulfide-linked homodimer in leukocytes and positively regulates neutrophil transepithelial migration. J. Biol. Chem. 280(43): 36132-36140
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