CD169 (Siglec-1) antibodies, human

CD169 (Siglec-1) antibodies, human

Clone: REA1176 | Dilution: 1:50
Clone REA1176 recognizes the human CD169, also known as siglec-1 or sialoadhesin, which is a type I transmembrane glycoprotein. It is the largest member of the siglec family, which are cell surface lectins that are able to bind to sialic acids and mediate interactions between proteins and carbohydrates. Siglec-1 is mainly expressed on tissue macrophages and dendritic cells and interacts with its counterreceptor on T cells, which has been identified as CD43.
Additional information: Clone REA1176 displays negligible binding to Fc receptors.

Alternative names

Siglec-1, SN, Sialoadhesin

Technical specifications

  • Antigen: CD169 (Siglec-1)
  • Clone: REA1176
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: Siglec-1, SN, Sialoadhesin
  • Entrez Gene ID: 6614
  • Molecular mass of antigen [kDa]: 181
  • Distribution of antigen: dendritic cells, macrophages
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Crocker, P.R. et al. (2001) Siglecs, sialic acids and innate immunity. Trends Immunol. 22(6): 337-342
    2. Hartnell, A. et al. (2001) Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 97: 288-296
    3. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166(6): 3637-3640
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