CD169 (Siglec-1) antibodies, human

CD169 (Siglec-1) antibodies, human

Clone: 7-239 | Dilution: 1:11
The monoclonal antibody 7-239 reacts with CD169, also known as siglec-1 or sialoadhesin, which is a type I transmembrane glycoprotein. It is the largest member of the siglec family, which are cell surface lectins that are able to bind to sialic acids and mediate interactions between proteins and carbohydrates. Siglec-1 is mainly expressed on tissue macrophages and dendritic cells and interacts with its counterreceptor on T cells, which has been identified as CD43.

Alternative names

Siglec-1, SN

Technical specifications

  • Antigen: CD169 (Siglec-1)
  • Clone: 7-239
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: Siglec-1, SN
  • Entrez Gene ID: 6614
  • Molecular mass of antigen [kDa]: 181
  • Distribution of antigen: bone marrow, macrophages, spleen
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin
  • Selected references

    1. van den Berg, T. K. et al. (2001) Cutting Edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor Sialoadhesin (Siglec-1). J. Immunol. 166: 3637-3640
    2. Hartnell, A. et al. (2001) Characterization of human sialoadhesin, a sialic acid binding receptor expressed by resident and inflammatory macrophage populations. Blood 97: 288-296
    3. Crocker, P.R. et al. (2001) Siglecs, sialic acids and innate immunity. Trends Immunol. 22(6): 337-342
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USD 87.00
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USD 232.00

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