CD161 antibodies, human

CD161 antibodies, human

Clone: REA631 | Dilution: 1:50
Clone REA631 recognizes the human CD161 antigen, a 80 kDa single-pass type II membrane protein, which is also known as natural killer cell surface protein P1A (NKR-P1A) or C-type lectin domain family 5 member B (CLEC5B). CD161 is expressed on most natural killer (NK) cells and subsets of T cells. In peripheral blood, CD161 is preferentially expressed on T cells of memory phenotype, but it can also be found on subsets of thymocytes and fetal liver T cells. CD161 has been implicated in triggering NK-mediated cytotoxicity, contributing to target cell recognition by NK cells.
Additional information: Clone REA631 displays negligible binding to Fc receptors.

Alternative names

NKR-P1A, HNKR-P1a, CLEC5B

Technical specifications

  • Antigen: CD161
  • Clone: REA631
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: NKR-P1A, HNKR-P1a, CLEC5B
  • Entrez Gene ID: 3820
  • Molecular mass of antigen [kDa]: 25
  • Distribution of antigen: liver, NK cells, T cells, thymocytes
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, Biotin, VioBright 515, PE-Vio615
  • Selected references

    1. Lanier, L. L. et al. (1994) Human NKR-P1A. A disulfide-linked homodimer of the C-type lectin superfamily expressed by a subset of NK and T lymphocytes. J. Immunol. 153: 2417-2428
    2. Pozo, D. et al. (2006) CD161 (human NKRP1A) signaling in NK cells involves the activation of acid sphingomyelinase. J. Immunol. 176: 2397-2406
    3. Takahashi, T. et al. (2006) Expression of CD161 (NKR-P1A) defines subsets of human CD4 and CD8 T cells with different functional activities.​ J. Immunol. 176: 211-216
Product options: 14
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 355.00
130-114-122

CD161-PE, human

for 30
tests
(1)
USD 104.00
130-113-596

CD161-PE, human

for 100
tests
(1)
USD 278.00
130-114-121

CD161-APC, human

for 30
tests
(1)
USD 124.00
130-113-595

CD161-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00
for 30
tests
(1)
USD 135.00
for 100
tests
(1)
USD 385.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 300.00

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