CD154 antibodies, human

CD154 antibodies, human

Clone: REA238 | Dilution: 1:11
Clone REA238 recognizes the human CD154 antigen, a 39 kDa transmembrane glycoprotein, also known as CD40L, gp39, T-BAM, TRAP, or Ly-62, which is a proinflammatory and prothrombotic ligand in the tumor necrosis factor family. CD154 is transiently up-regulated on activated CD4
T cells and plays an important role as a costimulatory molecule in T cell/antigen-presenting cell interactions through ligation of CD40. It mediates B cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL-4.
Additional information: Clone REA238 displays negligible binding to Fc receptors.

Alternative names

CD40L, CD40-L, gp39, T-BAM, TRAP, Ly-62, HIGM1, IGM

Technical specifications

  • Antigen: CD154
  • Clone: REA238
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD40L, CD40-L, gp39, T-BAM, TRAP, Ly-62, HIGM1, IGM
  • Entrez Gene ID: 959
  • Molecular mass of antigen [kDa]: 29
  • Cross-reactivity:
    cynomolgus monkey (
    Macaca fascicularis
    rhesus monkey (
    Macaca mulatta
  • Distribution of antigen: basophils, dendritic cells, lymphocytes, macrophages, mast cells, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PerCP-Vio700
  • Selected references

    1. Hollenbaugh, D. et al. (1992) The human T cell antigen gp39, a member of the TNF gene family, is a ligand for the CD40 receptor: expression of a soluble form of gp39 with B cell co-stimulatory activity. EMBO J. 11(12): 4313-4321
    2. Furman, M. et al. (2004) Release of soluble CD40L from platelets is regulated by glycoprotein IIb/IIIa and actin polymerization. J. Am. Coll. Cardiol. 43(12): 2319-2325
    3. Frentsch, M. et al. (2005)
      Direct access to CD4
      T cells specific for defined antigens according to CD154 expression.
      Nat. Med. 11: 1118-1124
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