CD153 antibodies – functional grade, mouse

CD153 antibodies – functional grade, mouse

Clone: RM153
The monoclonal antibody RM153 reacts with mouse CD153 (CD30 ligand), a 40 kDa type II membrane protein belonging to the NGF/TNF superfamily. It is expressed by activated CD4
+
and CD8
+
T cells. The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells. In the presence of the RM153 antibody this effect is blocked.
In vivo
treatment with this antibody is reported to inhibit or delay immune reactions.

Applications

This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.

Alternative names

TNFSF8, CD30LG, CD30L

Technical specifications

  • Antigen: CD153
  • Clone: RM153
  • Isotype: rat IgG2bκ
  • Alternative names of antigen: TNFSF8, CD30LG, CD30L
  • Entrez Gene ID: 21949
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: B cells, bone marrow, eosinophils, granulocytes, macrophages, monocytes, myeloid cells, neutrophils
  • Endotoxin level: Endotoxin levels have been tested and do not exceed 0.01 ng/µg of protein.
  • Product format: Antibodies are supplied in phosphate-buffered saline (PBS), pH 7.2. The product contains no preservative and is sterile filtered. Always handle under aseptic conditions.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. al-Shamkhani, A. et al. (1996) OX40 is differentially expressed on activated rat and mouse T cells and is the sole receptor for the OX40 ligand. Eur. J. Immunol. 26(8): 1695-1699
    2. Kjaergaard, J. et al. (2001) Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol. 167: 6669-6677
    3. Akiba, H. et al. (1999) CD28-independent costimulation of T cells by OX40 ligand and CD70 on activated B cells. J. Immunol. 162(12): 7058-7066
Product options: 1
500 µg in 0.5 mL
USD 355.00

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