The monoclonal antibody BNI3 reacts with human CD152, an integral membrane protein of the immunoglobin superfamily which is also called CTLA-4. CD152 is a negative regulator of T cell activation. It is transiently expressed on activated CD28+
T cells and is a ligand for CD80 and CD86. CD4+
regulatory T cells are reported to constitutively express CD152. CD152 may also be detected on B cells when cultured with activated T cells.
This pure – functional grade antibody is suited for cell culture functional assays, for example, blocking of receptor-ligand binding.
CTLA4, ALPS5, CD, CELIAC3, CTLA-4, GRD4, GSE, IDDM12