CD137L (4-1BBL) antibodies, human

Clone: REA254 | Dilution: 1:50
Clone REA254 recognizes the CD137L antigen, a type II transmembrane glycoprotein belonging to the TNF superfamily, which is also known as 4-1BB ligand or tumor necrosis factor ligand superfamily member 9. CD137L is expressed on a variety of antigen-presenting cells, including dendritic cells (DCs), B cells, and macrophages as well as on activated T Lymphocytes. CD137L cross-links its receptor, CD137, which is expressed on activated T cells, and co-stimulates T cell activities. Signaling through interaction with CD137 by soluble CD137L has been shown to cause T cell–expansion, cytokine induction, and upregulation of antiapoptotic genes, and to prevent activation-induced cell death. In monocytes, macrophages, and DCs, CD137L signaling induces activation, migration, survival, and differentiation. The role of CD137 signaling has been studied in several autoimmune processes, including rheumatoid arthritis, experimental autoimmune encephalomyelitis, and systemic lupus erythematosus.
Additional information: Clone REA254 displays negligible binding to Fc receptors.

Alternative names

TNFSF9, 4-1BBL, CD137 ligand, Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Technical specifications

  • Antigen: CD137L (4-1BBL)
  • Clone: REA254
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFSF9, 4-1BBL, CD137 ligand, Tumor necrosis factor ligand superfamily member 9 (TNFSF9)
  • Entrez Gene ID: 8744
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: B cells, macrophages, monocytes, dendritic cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, APC
  • Selected references

    1. Alderson, M. R. et al. (1994) Molecular and biological characterization of human 4-1BB and its ligand. Eur. J. Immunol. 24(9): 2219-2227
    2. Shao, Z. et al. (2011) CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction. J. Leukoc. Biol. 89: 21-29
    3. Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229(1): 192-215
    4. Vinay, D. S. et al. (2012) Immunotherapy of cancer with 4-1BB. Mol. Cancer Ther. 11: 1062-1070
Product options: 4
for 30
USD 138.00
for 100
USD 325.00
for 30
USD 126.00
for 100
USD 294.00

Related products

3 products available