CD134 (OX40) antibodies, human

CD134 (OX40) antibodies, human

Clone: REA621 | Dilution: 1:11
Clone REA621 recognizes the CD134 (OX40) antigen, a member of the tumor necrosis factor/nerve growth factor receptor (TNFR/NGFR) family. CD134 is a 50 kDa type I membrane glycoprotein expressed by activated T lymphocytes. The interaction of CD134 with OX40L has been implicated in T cell–dependent humoral response, regulation of primary T cell expansion, survival of T cells, size of the memory T cell pool, and regulation of tolerance in the CD4
+
T cell compartment. It is reported, that CD134 activates NF-κB through its interaction with adaptor proteins TRAF2 and TRAF5.
Additional information: Clone REA621 displays negligible binding to Fc receptors.

Alternative names

OX-40, OX40

Technical specifications

  • Antigen: CD134 (OX40)
  • Clone: REA621
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: OX-40, OX40
  • Entrez Gene ID: 7293
  • Molecular mass of antigen [kDa]: 27
  • Distribution of antigen: B cells, endothelial cells, fibroblasts, lymphocytes, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC-Vio770, Biotin, VioBright FITC
  • Selected references

    1. Kawamata, S. et al. (1998) Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. J. Biol. Chem. 273(10): 5808-5814
    2. Croft, M. et al. (2009) The significance of OX40 and OX40L to T-cell biology and immune disease. Immunol. Rev. 229(1): 173-191
    3. Zaunders, J. J. et al. (2009)
      High levels of human antigen-specific CD4
      +
      T cells in peripheral blood revealed by stimulated coexpression of CD25 and CD134 (OX40).
      J. Immunol. 183: 2827-2836
Product options: 6
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