CD133/2 (AC141) antibodies, human

CD133/2 (AC141) antibodies, human

Clone: AC141
CD133 is a novel 5-transmembrane cell surface antigen with a molecular weight of 117 kDa. CD133/2 (AC141) antibodies recognize epitope 2 of the human CD133 antigen (CD133/2). In the hematopoietic system, CD133 expression is restricted to a subset of CD34
stem and progenitor cells in human fetal liver, bone marrow, cord blood and peripheral blood. Additionally, CD133 is expressed by a small portion of CD34
cells in these tissues. The CD34
cell population, which includes CD34
cells, was shown to be capable of repopulating NOD/SCID mice. Recently, CD133 has also been found to be expressed on endothelial precursor cells and fetal neural stem cells as well as on developing epithelium. The putative murine homologue, prominin, which is expressed on neuroepithelial and epithelial mouse cells, was identified. In contrast to the other CD133 clones, the clone AC141 shows cross-reactivity with the intracellular protein cytokeratin 18.

Alternative names


Technical specifications

  • Antigen: CD133/2 (AC141)
  • Clone: AC141
  • Isotype: mouse IgG1
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: PROM1, AC133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4
  • Entrez Gene ID: 8842
  • Molecular mass of antigen [kDa]: 117
  • Distribution of antigen: brain, endothelial cells, epithelial cells, heart, hematopoietic stem cells, kidney, liver, lung, pancreas, placenta, ES and iPS cells, red blood cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: pure
  • Selected references

    1. Lai, J. et al. (2014)
      Id1 and NF-κB promote the generation of CD133
      and BMI-1
      keratinocytes and the growth of xenograft tumors in mice.
      Int. J. Oncol. 44(5): 1481-1489
    2. Yin, A. H. et al. (1997) AC133, a novel marker for human hematopoietic stem and progenitor cells. Blood 90: 5002-5012
    3. Piechaczek, C. (2001) CD133. J. Biol. Regul. Homeost. Agents 15: 101-102
    4. Bühring, H. J. et al. (1999) Expression of novel surface antigens on early hematopoietic cells. Ann. N. Y. Acad. Sci. 872: 25-39
    5. Gallacher, L. et al. (2000)
      Isolation and characterization of human CD34
      and CD34
      hematopoietic stem cells using cell surface markers AC133 and CD7.
      Blood 95(ARVO Annual Meeting Abstract): 2813-2820
    6. de Wynter, E. A. et al. (1998)
      cells isolated from cord blood are highly enriched in long-term culture-initiating cells, NOD/SCID-repopulating cells and dendritic cell progenitors.
      Stem Cells 16: 387-396
    7. Gehling, U. M. et al. (2000)
      In vitro
      differentiation of endothelial cells from AC133-positive progenitor cells.
      Blood 95: 3106-3112
    8. Peichev, M. et al. (2000)
      Expression of VEGFR-2 and AC133 by circulating human CD34
      cells identifies a population of functional endothelial precursors.
      Blood 95: 952-958
    9. Uchida, N. et al. (2000) Direct isolation of human central nervous system stem cells. Proc. Natl. Acad. Sci. U.S.A. 97: 14720-14725
    10. Corbeil, D. et al. (2000) The human AC133 hematopoietic stem cell antigen is also expressed in epithelial cells and targeted to plasma membrane protrusions. J. Biol. Chem. 275: 5512-5520
    11. Pötgens, A. J. et al. (2002) Monoclonal antibody CD133-2 (AC141) against hematopoietic stem cell antigen CD133 shows crossreactivity with cytokeratin 18. J. Histochem. Cytochem. 50(8): 1131-1134
    12. Miraglia, S. et al. (1997) A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood 90(12): 5013-5021
    13. Weigmann, A. et al. (1997) Prominin, a novel microvilli-specific polytopic membrane proteine of the apical surface of epithelial cells, is targeted to plasmalemmal protrusions of non-epithelial cells. Proc. Natl. Acad. Sci. U.S.A. 94: 12425-12430
  • Brochures and posters

Product options: 1
50 µg in 1 mL
USD 228.00

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