CD131 antibodies, human

CD131 antibodies, human

Clone: REA249 | Dilution: 1:11
Clone REA249 recognizes the human CD131 antigen, a type I transmembrane glycoprotein also known as IL-3R common subunit β or GM-CSF/IL-3/IL-5 receptor common β chain. CD131 forms heterodimers with the α subunit of the receptor complexes for human granulocyte-macrophage colony stimulating factor (GM-CSFR), interleukin 3 (IL-3R), and interleukin 5 (IL-5R). These cytokine receptors are expressed by several different cell types like neutrophils, eosinophils, monocytes, endothelial cells, fibroblasts, and hematopoietic progenitor cells.
Additional information: Clone REA249 displays negligible binding to Fc receptors.

Alternative names

CSF2RB, CDw131, IL3RB, IL5RB, SMDP5

Technical specifications

  • Antigen: CD131
  • Clone: REA249
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CSF2RB, CDw131, IL3RB, IL5RB, SMDP5
  • Entrez Gene ID: 1439
  • Molecular mass of antigen [kDa]: 96
  • Distribution of antigen: neutrophils, eosinophils, endothelial cells, fibroblasts, hematopoietic stem cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: APC
  • Selected references

    1. Rossjohn, J. et al. (2000) Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist. Blood 95(8): 2491-2498
    2. Hansen, G. et al. (2008) The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation. Cell 134(3): 496-507
Product options: 2
130-104-035

CD131-APC, human

for 30
tests
(1)
USD 124.00
130-104-003

CD131-APC, human

for 100
tests
(1)
USD 288.00

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