CD127 antibodies, human

CD127 antibodies, human

Clone: REA614 | Dilution: 1:50
Clone REA614 recognizes the CD127 antigen, which is the α-chain of the interleukin 7 (IL-7) receptor, a type I membrane glycoprotein. Signaling of IL-7 through the IL-7R requires both IL-7Rα and the common cytokine gamma chain (γc). CD127 can be identified on immature B cells through the early pre–B stage, on thymocytes, and on most mature T cells with transient down-regulation upon activation. On regulatory T cells CD127 is absent and its expression is inversely correlated with FoxP3 expression and suppressive function. CD127 is also used by thymic stromal derived lymphopoietin (TSLP) as part of a complex.
Additional information: Clone REA614 displays negligible binding to Fc receptors.

Alternative names

IL-7R, IL-7Rα, IL-17Ralpha, CDW127, ILRA

Technical specifications

  • Antigen: CD127
  • Clone: REA614
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL-7R, IL-7Rα, IL-17Ralpha, CDW127, ILRA
  • Entrez Gene ID: 3575
  • Molecular mass of antigen [kDa]: 50
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, VioBright 515, PE-Vio615
  • Selected references

    1. Fry, T. J. and Mackall, C. L. (2002) Interleukin-7: from bench to clinic. Blood 99: 3892-3904
    2. Seddiki, N. et al. (2006) Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatory and activated T cells. J. Exp. Med. 203: 1693-1700
    3. Liu, W. et al. (2006)
      CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4
      +
      T reg cells.
      J. Exp. Med. 203: 1701-1711
    4. Sudo, T. et al. (1993) Expression and function of the interleukin 7 receptor in murine lymphocytes. Proc. Natl. Acad. Sci. U.S.A. 90: 9125-9129
    5. Cupedo, T. et al. (2005) Development and activation of regulatory T cells in the human fetus. Eur. J. Immunol. 35: 383-390
    6. Armitage, R. J. et al. (1991) Expression of receptors for interleukin 4 and interleukin 7 on human T cells. Adv. Exp. Med. Biol. 292: 121-130
Product options: 14
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 355.00
130-113-976

CD127-PE, human

for 30
tests
(1)
USD 104.00
130-113-414

CD127-PE, human

for 100
tests
(1)
USD 278.00
130-113-975

CD127-APC, human

for 30
tests
(1)
USD 124.00
130-113-413

CD127-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 135.00
for 100
tests
(1)
USD 385.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 300.00

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