CD123 antibodies, human

CD123 antibodies, human

Clone: REA918 | Dilution: 1:50
Clone REA918 recognizes the human CD123 antigen, a type I transmembrane glycoprotein, which is also known as interleukin 3 (IL-3) receptor α-chain and is the primary low-affinity subunit of the IL-3 receptor. CD123 associates with CD131, the common β-chain of the IL-3, IL-5, and GM-CSF receptor, to form the high-affinity IL-3 receptor. The IL-3 receptor is involved in cell signaling for cell growth and differentiation. In peripheral blood, the CD123 antigen is expressed at high levels only on plasmacytoid dendritic cells and basophilic granulocytes but at low levels also on monocytes, eosinophilic granulocytes, myeloid dendritic cells, and subsets of hematopoietic progenitor cells.
Additional information: Clone REA918 displays negligible binding to Fc receptors.

Alternative names

IL3RA, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, IL-3Rα

Technical specifications

  • Antigen: CD123
  • Clone: REA918
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL3RA, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, IL-3Rα
  • Entrez Gene ID: 3563
  • Molecular mass of antigen [kDa]: 41
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
  • Distribution of antigen: dendritic cells, granulocytes, mast cells, megakaryocytes, monocytes, basophils, eosinophils, hematopoietic stem cells, myeloid cells, plasma cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin, VioBright 667
  • Selected references

    1. Miyajima, A. et al. (1993) Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82(7): 1960-1974
    2. Chen, J. et al. (2009) A new isoform of interleukin-3 receptor {alpha} with novel differentiation activity and high affinity binding mode. J. Biol. Chem. 284(9): 5763-5773
    3. Choi, K.-D. et al. (2011) Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells. Nat. Protoc. 6(3): 296-313
Product options: 22
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00
130-115-357

CD123-PE, human

for 30
tests
(1)
USD 104.00
130-115-264

CD123-PE, human

for 100
tests
(1)
USD 278.00
130-115-358

CD123-APC, human

for 30
tests
(1)
USD 124.00
130-115-265

CD123-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 130.00
for 100
tests
(1)
USD 315.00
for 30
tests
(1)
USD 158.00
for 100
tests
(1)
USD 345.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 148.00
for 100
tests
(1)
USD 320.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 242.00
for 30
tests
(1)
USD 176.00
for 100
tests
(1)
USD 415.00

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