CD122 (IL-2Rβ) antibodies, human

CD122 (IL-2Rβ) antibodies, human

Clone: REA167 | Dilution: 1:11
Clone REA167 recognizes CD122, the 75 KDa β subunit of the high and intermediate affinity interleukin 2 receptor (IL-2R). CD122 is a type I transmembrane protein, and together with α subunit (CD25) or with α and γ (CD132) subunit, it forms the heteromeric intermediate and high affinity IL-2 receptors, respectively. In addition, CD122 is also a component of the IL-15 receptor complex. Expression of CD122 is found constitutively in CD8 cytotoxic T cells but not in CD4 Tʜ cells and is further induced upon T cell activation. CD16
+
NK lymphocytes also express CD122 constitutively. CD122 is essential for IL-2 signaling.
Additional information: Clone REA167 displays negligible binding to Fc receptors.      

Alternative names

IL2RB, IL-15RB, P70-75

Technical specifications

  • Antigen: CD122 (IL-2Rβ)
  • Clone: REA167
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL2RB, IL-15RB, P70-75
  • Entrez Gene ID: 3560
  • Molecular mass of antigen [kDa]: 58
  • Distribution of antigen: NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, PE-Vio770, Biotin
  • Selected references

    1. Gesbert, F. et al. (2005) IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rß transgenic mice. Int. Immunol. 17: 1093-1102
    2. Friedmann, M. C. et al. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. U.S.A. 93(5): 2077-2082
    3. Migone, T. S. et al. (1998) Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol. Cell. Biol. 18(11): 6416-6422
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