CD121b (IL-1R2) antibodies, human

CD121b (IL-1R2) antibodies, human

Clone: REA744 | Dilution: 1:50
Clone REA744 recognizes the human CD121b antigen, also known as interleukin-1 receptor type II (IL-1R2). CD121b is a 60 kDa cytokine receptor, which is a ligand for interleukin-1 (IL-1). There are two forms of the IL-1 receptors. The type I receptor is mainly involved in transmitting the inflammatory effects of IL-1 while type II receptor plays a role as a suppressor of IL-1 activity by competing for IL-1 binding.
Additional information: Clone REA744 displays negligible binding to Fc receptors.

Alternative names

IL-1R-2, IL-1R-II, IL-1RII, IL-1R-beta, IL-1Rb

Technical specifications

  • Antigen: CD121b (IL-1R2)
  • Clone: REA744
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: IL-1R-2, IL-1R-II, IL-1RII, IL-1R-beta, IL-1Rb
  • Entrez Gene ID: 7850
  • Molecular mass of antigen [kDa]: 44
  • Distribution of antigen: T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, Biotin, PE, APC, VioBright FITC
  • Selected references

    1. McMahan, C. J. et al. (1991) A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10(10): 2821-2832
    2. Kuno, K. et al. (1994) The IL-1 receptor signaling pathway. J. Leukoc. Biol. 56(5): 542-547
    3. Liu, C. et al. (1996) Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. J. Biol. Chem. 271(34): 20965-20972
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