CD120a (TNF-RI) antibodies, human

Clone: REA252 | Dilution: 1:11
Clone REA252 recognizes the extracellular part of the membrane-bound and soluble form of the CD120a antigen, a 55 kDa type I transmembrane glycoprotein also known as tumor necrosis factor receptor type I (TNF-RI) or p55. CD120a belongs to the TNF receptor superfamily and is mainly expressed by monocytes, macrophages, and neutrophils. It is also expressed by a variety of cell lines, tumor cells, and normal cell types including T cells, endothelial cells, hepatocytes, chondrocytes, and fibroblasts. Binding of TNF-α to its main receptor CD120a triggers signaling which is extremely complex, leading to both cell death and survival signals. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of human diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease.
Additional information: Clone REA252 displays negligible binding to Fc receptors.

Alternative names

TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1

Technical specifications

  • Antigen: CD120a (TNF-RI)
  • Clone: REA252
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: TNFRSF1A, FPF, MS5, TBP1, p55, p60, TNF-R1
  • Entrez Gene ID: 7132
  • Molecular mass of antigen [kDa]: 48
  • Distribution of antigen: granulocytes, monocytes, macrophages, neutrophils, T cells, endothelial cells, chondrocytes, fibroblasts, liver, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE-Vio770, Biotin
  • Selected references

    1. Grell, M. et al. (1998) The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor. Proc. Natl. Acad. Sci. U.S.A. 95: 570-575
    2. Bianchi, K. et al. (2009) A tangled web of ubiquitin chains: breaking news in TNF-R1 signaling. Mol. Cell 36(5): 736-742
    3. Hijdra, D. et al. (2012) Differential expression of TNFR1 (CD120a) and TNFR2 (CD120b) on subpopulations of human monocytes. J. Inflamm. 9(1): 38
Product options: 4
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USD 89.00
for 100
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