CD11c antibodies, human

CD11c antibodies, human

Clone: REA618 | Dilution: 1:50
Clone REA618 recognizes the human CD11c antigen, a 145–150 kDa type I transmembrane glycoprotein, which is also known as integrin αX or CR4. It is expressed on monocytes, macrophages, NK cells, granulocytes, myeloid dendritic cells (MDCs), and subsets of T and B cells. On myeloid dendritic cells, CD11c is highly expressed on type 1 myeloid dendritic cells (CD1c (BDCA-1)
+
CD123
low
MDC1s) and low on type 2 myeloid dendritic cells (CD1c (BDCA-1)
CD123
MDC2s). CD11c, also known as integrin integrin αX or CR4, has been reported to play a role in adhesion and CTL killing through its interactions with fibrinogen, CD54, and iC3b.
Additional information: Clone REA618 displays negligible binding to Fc receptors.

Alternative names

95, CR4, integrin αX, ITGAX, p150

Technical specifications

  • Antigen: CD11c
  • Clone: REA618
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: 95, CR4, integrin αX, ITGAX, p150
  • Entrez Gene ID: 3687
  • Molecular mass of antigen [kDa]: 126
  • Distribution of antigen: B cells, dendritic cells, granulocytes, leukemia cells, lymphocytes, macrophages, monocytes, myeloid cells, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio615, PE-Vio770, APC-Vio770, Biotin, VioBlue
  • Selected references

    1. Dzionek, A. et al. (2000) BDCA-2, BDCA-3, BDCA-4: Three markers for distinct subsets of dendritic cells in human peripheral blood. J. Immunol. 165: 6037-6046
    2. Bendiss-Vermare, N. et al. (2001)
      Human thymus contains IFN-alpha-producing CD11c
      , myeloid CD11c
      +
      , and mature interdigitating dendritic cells.
      J. Clin. Invest. 107: 835-844
    3. Barclay, A. N. et al. (1997) In: The Leukocyte Antigen Facts Book, Academic Press, San Diego, CA. (2nd edition): 161-162
Product options: 15
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 345.00
130-114-113

CD11c-PE, human

for 30
tests
(1)
USD 102.00
130-113-587

CD11c-PE, human

for 100
tests
(1)
USD 274.00
130-114-110

CD11c-APC, human

for 30
tests
(1)
USD 122.00
130-113-584

CD11c-APC, human

for 100
tests
(1)
USD 284.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 296.00
for 30
tests
(1)
USD 144.00
for 100
tests
(1)
USD 310.00
for 30
tests
(1)
USD 138.00
for 100
tests
(1)
USD 325.00
for 30
tests
(1)
USD 81.00
for 100
tests
(1)
USD 238.00
for 100
tests
(1)
USD 310.00

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