CD11b antibodies, human and mouse

CD11b antibodies, human and mouse

Clone: M1/70.15.11.5 | Dilution: 1:50
CD11b, also known as Mac-1 α or integrin αM chain, is part of the CD11b/CD18 heterodimer (Mac-1 α, Mβ2 integrin), also known as the C3 complement receptor. It functions as a receptor for complement (C3bi), fibrinogen, or clotting factor X. In humans, CD11b is strongly expressed on myeloid cells and weakly expressed on NK cells and some activated lymphocytes as well as on microglia in the brain. In mice, the CD11b antigen is expressed on monocytes/macrophages and microglia. To a lower extent it is expressed on granulocytes, NK cells, CD5
+
B-1 cells, and subsets of dendritic cells. The monoclonal M1/70.15.11.5 antibody recognizes the human, mouse, and non-human primate CD11b antigen.

Alternative names

ITGAM, CR3A, Mac-1 α, MAC1A, MO1A, SLEB6, integrin αM

Technical specifications

  • Antigen: CD11b
  • Clone: M1/70.15.11.5
  • Isotype: rat IgG2bκ
  • Isotype control: Rat IgG2b – isotype control antibodies
  • Alternative names of antigen: ITGAM, CR3A, Mac-1 α, MAC1A, MO1A, SLEB6, integrin αM
  • Entrez Gene ID: 3684
  • Molecular mass of antigen [kDa]: 125
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
  • Distribution of antigen: B cells, dendritic cells, granulocytes, macrophages, monocytes, NK cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio770, APC-Vio770, PerCP-Vio700, Biotin, pure
  • Selected references

    1. Lebson, L. et al. (2010) Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J. Neurosci. 30(29): 9651-9658
    2. Liu, T. et al. (2014)
      Gr-1
      +
      CD11b
      +
      cells facilitate Lewis lung cancer recurrence by enhancing neovasculature after local irradiation.
      Sci. Rep. 4: 4833
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tests
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USD 81.00
for 100
tests
(1)
USD 238.00
100 µg in 1 mL
USD 320.00

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