CD11a antibodies, human

CD11a antibodies, human

Clone: REA378 | Dilution: 1:11
Clone REA378 recognizes the human CD11a antigen, a single-pass type I membrane protein also known as integrin α-L (ITGAL). Integrins are heterodimeric adhesion molecules comprised of α- and β-subunits that participate in immune cell interactions as well as in immune cell-extracellular matrix interactions. CD11a combines with CD18 (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 is a receptor for CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), and CD242 (ICAM-4). It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T cell–mediated killing, and antibody dependent killing by granulocytes and monocytes. Interactions between LFA-1 and CD54 (ICAM-1) play a critical role in T cell–B cell collaboration.
Additional information: Clone REA378 displays negligible binding to Fc receptors.

Alternative names

ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain

Technical specifications

  • Antigen: CD11a
  • Clone: REA378
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: ITGAL, LFA-1, LFA1A, Leukocyte function-associated molecule 1 α chain
  • Entrez Gene ID: 3683
  • Molecular mass of antigen [kDa]: 126
  • Cross-reactivity:
    rhesus monkey (
    Macaca mulatta
    )
    ,
    cynomolgus monkey (
    Macaca fascicularis
    )
    ,
    chimpanzee (
    Pan troglodytes
    )
    ,
    olive baboon (
    Papio anubis
    )
    , capuchin monkey, horse, cattle (bovine, cow), sheep, dog, rabbit
  • Distribution of antigen: leukocytes, T cells, granulocytes, monocytes, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, PE-Vio770, Biotin
  • Selected references

    1. Lowes, M. A. et al. (2005) Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a). Proc. Natl. Acad. Sci. U.S.A. 102(52): 19057-19062
    2. Larson, R. S. et al. (1989) Primary structure of the leukocyte function-associated molecule-1 alpha subunit: an integrin with an embedded domain defining a protein superfamily. J. Cell Biol. 108(2): 703-712
    3. Zhou, Y. et al. (2012) Usefulness of CD11a and CD18 in flow cytometric immunophenotypic analysis for diagnosis of acute promyelocytic leukemia. Am. J. Clin. Pathol. 138(5): 744-750
Product options: 12
for 30
tests
(1)
USD 82.00
for 100
tests
(1)
USD 232.00
130-105-479

CD11a-PE, human

for 30
tests
(1)
USD 97.00
130-105-436

CD11a-PE, human

for 100
tests
(1)
USD 272.00
130-105-480

CD11a-APC, human

for 30
tests
(1)
USD 130.00
130-105-437

CD11a-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 126.00
for 100
tests
(1)
USD 300.00
for 30
tests
(1)
USD 142.00
for 100
tests
(1)
USD 305.00
for 30
tests
(1)
USD 87.00
for 100
tests
(1)
USD 232.00

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