CD117 antibodies, human

CD117 antibodies, human

Clone: A3C6E2 | Dilution: 1:11
CD117, also known as c-kit or SCF receptor, is a 145 kDa receptor tyrosine kinase that is involved in stem cell signaling, activation, and proliferation. The CD117 antigen is expressed on about 1–3% of mononuclear cells from peripheral blood mononuclear cells (PBMCs) or cord blood, and on up to 10% of bone marrow cells. CD117 is further expressed on basophils, myeloid dendritic cells, TCRα/β
T cells, CD19
B cells, and CD56
NK cells, as well as on mast cells, melanocytes, and AML (acute myeloid leukemia) blasts.
Clone A3C6E2 recognizes a different epitope than clone AC126 and may interfere with SCF-binding. It is therefore not recommended for indirect cell isolation, but is optimal for flow cytometric analysis of cells separated with the CD117 MicroBead Kit, human.

Alternative names

c-kit, PBT, SCFR, KIT

Technical specifications

  • Antigen: CD117
  • Clone: A3C6E2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: c-kit, PBT, SCFR, KIT
  • Entrez Gene ID: 3815
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: B cells, bone marrow, brain, cancer stem cells, endothelial cells, fibroblasts, hematopoietic stem cells, kidney, leukemia cells, liver, lung, mast cells, megakaryocytes, myeloid cells, NK cells, red blood cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE-Vio770, PE
  • Selected references

    1. Kubo, H. et al. (2008) Increased cardiac myocyte progenitors in failing human hearts. Circulation 118: 649-657
    2. Bühring, H. J. et al. (1991) The product of the proto-oncogene c-kit (P145c-kit) is a human bone marrow surface antigen of hematopoietic precursor cells which is expressed on a subset of acute non-lymphoblastic cells. Leukemia 5: 854-860
    3. Berglund, E. et al. (2013)
      Evidence for Ca
      -regulated ATP release in gastrointestinal stromal tumors.
      Exp. Cell Res. 319(8): 1229-1238
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