CD115 antibodies, mouse

CD115 antibodies, mouse

Clone: AFS98 | Dilution: 1:50
Clone AFS98 recognizes the protein tyrosine kinase transmembrane receptor for macrophage colony-stimulating factor (M-CSF), also known as CSF-1 and interleukin 34 (IL-34). CD115 is a single-pass type I membrane protein. Receptor activation induces homo-dimerization, which leads to phosphorylation and ubiquitinylation of intracellular residues. CD115 is expressed on mouse monocytes, macrophages, and osteoclasts, as well as on common dendritic cell precursors and macrophage/dendritic cell precursors.

Alternative names

Csfmr, Fim-2, FMS, M-CSFR, CSF-1R, c-fms

Technical specifications

  • Antigen: CD115
  • Clone: AFS98
  • Isotype: rat IgG2aκ
  • Isotype control: Rat IgG2a – isotype control antibodies
  • Alternative names of antigen: Csfmr, Fim-2, FMS, M-CSFR, CSF-1R, c-fms
  • Entrez Gene ID: 12978
  • Molecular mass of antigen [kDa]: 107
  • Distribution of antigen: breast, dendritic cells, macrophages, myeloid leukemia cells, osteoclasts, smooth muscle
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE
  • Selected references

    1. Sunderkötter, C. et al. (2004) Subpopulations of mouse blood monocytes differ in maturation stage and inflammatory response. J. Immunol. 172: 4410-4417
    2. Auffray, C. et al. (2009)
      CX
      3
      CR1
      +
      CD115
      +
      CD135
      +
      common macrophage/DC precursors and the role of CX
      3
      CR1 in their response to inflammation.
      J. Exp. Med. 206(3): 595-606
    3. Murayama, T. et al. (1999) Intraperitoneal administration of anti-c-fms monoclonal antibody prevents initial events of atherogenesis but does not reduce the size of advanced lesions in apolipoprotein E-deficient mice. Circulation 99: 1740-1746
    4. Breslin W. L. et al. (2013) Mouse blood monocytes: Standardizing their identification and analysis using CD115. J. Immunol. Methods 390(1-2): 1-8
    5. Sudo, T. et al. (1995) Functional hierarchy of c-kit and c-fms in intramarrow production of CFU-M. Oncogene 11: 2469-2476
Product options: 1
130-122-018

CD115-PE, mouse

30 µg in 200 µL (1)
USD 55.00

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