CD112 antibodies, human

CD112 antibodies, human

Clone: REA1195 | Dilution: 1:50
Clone REA1195 recognizes the human CD112 antigen, a Single-pass type I membrane protein which is also known as Nectin-2, Herpesvirus entry mediator B (HveB) or Poliovirus receptor-related protein 2 (PRR2). Nectins are Ca2+-independent cell adhesion molecules that consist of 4 members: CD111 (Nectin-1), CD112 (Nectin-2), CD113 (Nectin-3), and Nectin-4. CD112 is one of the plasma membrane components of adherens junctions and is widely expressed in human tissues, including hematopoietic cells. It is also over-expressed in various cancers, e.g. breast and ovarian cancers. It has been reported to regulate cell adhesion between epithelial cells through the formation of trans-dimers between adjacent cells. CD112-mediated cell adhesion induces the formation of E-cadherin-based adherens junctions followed by the formation of claudin-based tight junctions. In addition to its function as a cell adhesion molecule, previous studies have suggested that CD112 acts as an organizer of Sertoli cell-spermatid junctions in the testis and of synapse formation by neurons and as an entry receptor for viruses. CD112 is also known to be one of the ligands of CD226 (DNAM-1) and TIGIT.
Additional information: Clone REA1195 displays negligible binding to Fc receptors.

Alternative names

PRR2, HveB, Nectin-2, PVRL2, NECTIN2

Technical specifications

  • Antigen: CD112
  • Clone: REA1195
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: PRR2, HveB, Nectin-2, PVRL2, NECTIN2
  • Entrez Gene ID: 5819
  • Molecular mass of antigen [kDa]: 55
  • Distribution of antigen: endothelial cells, leukocytes, epithelial cells, testicle, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, Biotin
  • Selected references

    1. Eberlé, F. et al. (1995) The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene. Gene 159(2): 267-272
    2. Pende, D. et al. (2005) PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis. Mol. Immunol. 42(4): 463-469
    3. Oshima, T. et al. (2013) Nectin-2 is a potential target for antibody therapy of breast and ovarian cancers. Mol. Cancer 12(60): 4598-4612
Product options: 8
130-122-782

CD112-PE, human

for 30
tests
(1)
USD 102.00
130-122-770

CD112-PE, human

for 100
tests
(1)
USD 278.00
130-122-783

CD112-APC, human

for 30
tests
(1)
USD 122.00
130-122-771

CD112-APC, human

for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 130.00
for 100
tests
(1)
USD 300.00
for 30
tests
(1)
USD 83.00
for 100
tests
(1)
USD 241.00