CD104 (Integrin β4) antibodies, mouse

CD104 (Integrin β4) antibodies, mouse

Clone: REA456 | Dilution: 1:10
Clone REA456 recognizes the mouse CD104 antigen, a single-pass type I membrane protein which is also known as integrin β4 (Itgb4). Integrins are a family of heterodimeric glycoprotein receptors and exist as non-covalently bound α and β subunits. CD104 interacts with α6 integrin and serves as receptor for laminin and component of hemidesmosomes. Expression of α6β4 integrin is found in the basal aspect of stratified epithelia such as epidermis, stratified squamous epithelium of squamous mucosa, urotheliumin, and certain tumor cells. CD104 is likely to play a pivotal role in the biology of invasive carcinoma.
Additional information: Clone REA456 displays negligible binding to Fc receptors.

Alternative names

Itgb4

Technical specifications

  • Antigen: CD104 (Integrin β4)
  • Clone: REA456
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: Itgb4
  • Entrez Gene ID: 192897
  • Molecular mass of antigen [kDa]: 199
  • Distribution of antigen: epithelial cells, tumor cells, other
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, Biotin
  • Selected references

    1. Simon-Assmann, P. et al. (1994) Differential expression of laminin isoforms and alpha 6-beta 4 integrin subunits in the developing human and mouse intestine. Dev. Dyn. 201(1): 71-85
    2. Murgia, C. et al. (1998) Cell cycle and adhesion defects in mice carrying a targeted deletion of the integrin beta4 cytoplasmic domain. EMBO J. 17(14): 3940-3951
    3. Pal-Ghosh, S. et al. (2011) MMP9 cleavage of the β4 integrin ectodomain leads to recurrent epithelial erosions in mice. J. Cell. Sci. 124(Pt 15): 2666-2675
Product options: 8
9 µg in 300 µL (1)
USD 79.00
30 µg in 1 mL (1)
USD 164.00
9 µg in 300 µL (1)
USD 41.00
30 µg in 1 mL (1)
USD 51.00
9 µg in 300 µL (1)
USD 51.00
30 µg in 1 mL (1)
USD 76.00
9 µg in 300 µL (1)
USD 26.00
30 µg in 1 mL (1)
USD 51.00

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