Anti-TRA-1-85 (CD147) antibodies, human

Anti-TRA-1-85 (CD147) antibodies, human

Clone: REA476 | Dilution: 1:11
Clone REA476 recognizes the human TRA-1-85 antigen, a single-pass type I membrane protein, which is also known as CD147, basigin, or extracellular matrix metalloproteinase inducer (EMMPRIN). TRA-1-85 is expressed by many cell types, including epithelial cells, endothelial cells, leukocytes, and tumor cells. It is present in vascular endothelium in non-neoplastic regions of the brain, and in tumor cells but not in proliferating blood vessels in malignant gliomas. TRA-1-85 has been implicated in a variety of physiological and pathological activities. It is best known for its ability to function as extracellular matrix metalloproteinase inducer, but has also been shown to regulate lymphocyte responsiveness, monocarboxylate transporter expression, and spermatogenesis. TRA-1-85 is often used to discern human cells from non-human cells in multiple applications including animal transplantation studies.
Additional information: Clone REA476 displays negligible binding to Fc receptors.

Alternative names

EMMPRIN, Basigin (BSG), Neurothelin, 5F7, BSG, TCSF, OKa, CD147

Technical specifications

  • Antigen: TRA-1-85 (CD147)
  • Clone: REA476
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: EMMPRIN, Basigin (BSG), Neurothelin, 5F7, BSG, TCSF, OKa, CD147
  • Entrez Gene ID: 682
  • Molecular mass of antigen [kDa]: 40
  • Distribution of antigen: epithelial cells, endothelial cells, leukocytes, tumor cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Williams, B. P. et al. (1988) Biochemical and genetic analysis of the OKa blood group antigen. Immunogenetics 27(5): 322-329
    2. Biswas, C. et al. (1995) The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily. Cancer Res. 55(2): 434-439
    3. Yurchenko, V. et al. (2006) Dealing with the family: CD147 interactions with cyclophilins. Immunology 117(3): 301-309
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