Anti-TIM-3 antibodies, human

Clone: F38-2E2 | Dilution: 1:11
The monoclonal antibody F38-2E2 recognizes human cell surface molecule TIM-3, which is expressed on activated T cells, especially Tʜ1 cells, monocytes, macrophages, and dendritic cells. TIM-3 has been proposed to inhibit Tʜ1-mediated immune responses and regulates Tʜ1 and Tʜ17 cytokine secretion. The interaction of TIM-3 and its ligand galectin-9 induces apoptosis of Tʜ1 cells.

Alternative names

HAVCR2, CD366, HAVcr-2, KIM-3, TIMD-3

Technical specifications

  • Antigen: TIM-3
  • Clone: F38-2E2
  • Isotype: mouse IgG1κ
  • Isotype control: Mouse IgG1 – isotype control antibodies
  • Alternative names of antigen: HAVCR2, CD366, HAVcr-2, KIM-3, TIMD-3
  • Entrez Gene ID: 84868
  • Molecular mass of antigen [kDa]: 31
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, Biotin
  • Selected references

    1. Monney, L. et al. (2002) Tʜ1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541
    2. Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6(12): 1245-1252
    3. Hastings, W. D. et al. (2009)
      TIM-3 is expressed on activated human CD4
      T cells and regulates Tʜ1 and Tʜ17 cytokines.
      Eur. J. Immunol. 39(9): 2492-2501
    4. Hirsch, S. et al. (1983) Polymorphic expression of a neutrophil differentiation antigen revealed by monoclonal antibody 7/4. Immunogenetics 18(3): 229-239
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for 100
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