Anti-STAT3 pS727 antibodies, human

Anti-STAT3 pS727 antibodies, human

Clone: REA324 | Dilution: 1:11
Clone REA324 recognizes the signal transducer and activator of transcription 3 (STAT3) antigen phosphorylated at serine 727 (pS727). STAT3 expression is found ubiquitously. It is activated in response to various growth factors, hormones, and cytokines, and has an important role in their signaling. When these ligands bind to the specific transmembrane STAT3 receptor, STAT3 becomes activated by tyrosine phosphorylation of two important phosphorylation sites, pY705 and pS727. The dimeric STAT3 translocates to the nucleus, where it binds to consensus STAT3 binding sequences within the promoter region of target genes and thereby activates their transcription. The persistent activation of STAT3 also mediates tumor-promoting inflammation. STAT3 promotes pro-oncogenic inflammatory pathways in tumor inflammation and immunity, including nuclear factor-κB and interleukin-6-GP130-Janus kinase pathways, and by opposing STAT1- and NF-κB-mediated T helper 1 anti-tumor immune responses.
Additional information: Clone REA324 displays negligible binding to Fc receptors.

Alternative names

ADMIO, APRF, HIES

Technical specifications

  • Antigen: STAT3 pS727
  • Clone: REA324
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (I) antibodies
  • Alternative names of antigen: ADMIO, APRF, HIES
  • Entrez Gene ID: 6774
  • Molecular mass of antigen [kDa]: 88
  • Distribution of antigen: ubiquitous
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: The antibody is suited for staining of formaldehyde-fixed cells.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, Vio515
  • Selected references

    1. Sakaguchi, M. et al. (2012) Role and regulation of STAT3 phosphorylation at Ser727 in melanocytes and melanoma cells J. Invest. Dermatol. 132(7): 1877-1885
    2. Yu, H. et al. (2009) STATs in cancer inflammation and immunity: a leading role for STAT3 Nat. Rev. Cancer 9(11): 798-809
    3. Zhang, X. et al. (1995) Requirement of serine phosphorylation for formation of STAT-promoter complexes Science 267(5206): 1990-1994
Product options: 6
for 30
tests
(1)
USD 97.00
for 100
tests
(1)
USD 272.00
for 30
tests
(1)
USD 124.00
for 100
tests
(1)
USD 288.00
for 30
tests
(1)
USD 130.00
for 100
tests
(1)
USD 325.00

Related products

4 products available