Clone REA404 recognizes the human slug antigen, a zinc finger transcriptional repressor also known as SNAI2. Slug is an inducer of the epithelial to mesenchymal transition (EMT) which is a highly conserved developmental program activated during mesoderm formation and neural crest development. This program also promotes dissemination of single malignant cells from primary epithelial tumors. During EMT, cells discard their epithelial characteristics, including cell adhesion and polarity, reorganize their cytoskeleton and acquire a mesenchymal morphology and the ability to migrate. One of the hallmarks of EMT is the functional loss of the cell-cell junction protein E-cadherin. Several transcription factors including slug have been identified to repress E-cadherin expression, which plays important roles in cell adhesion and in the maintenance of tissue structure. These EMT transcription factors bind to E-box elements in the promoter region of E-cadherin leading to transcriptional repression of junctional complexes and induction of the mesenchymal phenotype.
Additional information: Clone REA404 displays negligible binding to Fc receptors.
SNAI2, SLUGH1, SNAIL2, WS2D, SLUG, SLUGH