Anti-Siglec-5/Siglec-14 antibodies, human

Anti-Siglec-5/Siglec-14 antibodies, human

Clone: REA393 | Dilution: 1:11
Clone REA393 recognizes the human siglec-5 and siglec-14 antigens, which are both single pass transmembrane protein members of the immunoglobulin superfamily. Siglec-5 is also known as CD170. Siglec-5 has four extracellular Ig-like domains and a cytosolic inhibitory motif. Siglec-14 was discovered with three Ig-like domains and has almost complete sequence identity with siglec-5 at the first two Ig-like domains, shows a glycan binding preference similar to that of siglec-5, and associates with the activating adapter protein DAP12. Siglec-5 is expressed on granulocytes and monocytes as well as on plasmacytoid dendritic cells, monocyte-derived dendritic cells, and macrophages. It is potentially involved in the negative regulation of innate immune responses, and also suggested to be a useful diagnostic and therapeutic marker for acute myelogenous leukemia. Siglec-14 is expressed on granulocytes and B cells. Some individuals lack the expression of siglec-14, while they all express siglec-5.
Additional information: Clone REA393 displays negligible binding to Fc receptors.

Alternative names

CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14

Technical specifications

  • Antigen: Siglec-5/Siglec-14
  • Clone: REA393
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CD170, CD33L2, OB-BP2, OBBP2, SIGLEC5, Siglec14
  • Entrez Gene ID: 8778, 100049587
  • Molecular mass of antigen [kDa]: 51
  • Distribution of antigen: granulocytes, monocytes, dendritic cells, macrophages, B cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: VioBright FITC, PE, APC, PE-Vio770, APC-Vio770, Biotin
  • Selected references

    1. Cornish, A. L. et al. (1998) Characterization of Siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Blood 92(6): 2123-2132
    2. Ali, S. R. et al. (2014) Siglec-5 and Siglec-14 are polymorphic paired receptors that modulate neutrophil and amnion signaling responses to group B Streptococcus. J. Exp. Med. 211(6): 1231-1242
    3. Angata, T. et al. (2006) Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20(12): 1964-1973
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