Anti-PTK7 (CCK-4) antibodies, human

Anti-PTK7 (CCK-4) antibodies, human

Clone: REA836 | Dilution: 1:50
Clone REA836 recognizes human protein tyrosine kinase-7 (PTK7). PTK7, also known as colon carcinoma kinase-4 (CCK-4), is a receptor protein tyrosine kinase (RPTK)–like molecule that contains a catalytically inactive tyrosine kinase domain. PTK7 was identified to be important for neural development as a regulator of planar cell polarity, being required for convergent extension movement and neural tube closure. Using the Anti-PTK7 (CCK-4) antibody, PTK7 expression was recently analyzed on blood and bone marrow cells. PTK7 was shown to be expressed on plasmacytoid dendritic cells, CD141 (BDCA-3)
high
type-2 myeloid dendritic cells, and CD34
+
hematopoietic progenitor cells (HPCs). PTK7 was detected on early (CD34
+
CD133
+
) and late (CD34
+
CD133
) HPCs. In tonsils, PTK7 was also found on some T cells.
Additional information: Clone REA836 displays negligible binding to Fc receptors.

Alternative names

CCK-4, CCK4

Technical specifications

  • Antigen: PTK7 (CCK-4)
  • Clone: REA836
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CCK-4, CCK4
  • Entrez Gene ID: 5754
  • Molecular mass of antigen [kDa]: 115
  • Distribution of antigen: bone marrow, dendritic cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: PE, APC, PE-Vio615, PE-Vio770, Biotin
  • Selected references

    1. Mossie, K. et al. (1995) Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene 11: 2179-2184
    2. Park, S. K. et al. (1996) Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. J. Biochem. 119(2): 235-239
    3. Katoh, M. and Katoh, M. (2007) Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. Int. J. Mol. Med. 20: 405-409
    4. Xiao, Z. et al. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14: 1769-1775
    5. Lu, X. et al. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430: 93-98
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