Anti-P2X7R antibodies, mouse

Anti-P2X7R antibodies, mouse

Clone: REA875 | Dilution: 1:50
Clone REA875 recognizes the mouse P2X7R antigen, also known as P2RX7 or P2X7 (P2X purinoceptor 7), which is a receptor for ATP that acts as a ligand-gated ion channel. P2X7R is involved in different inflammatory, immune, neurologic, and musculoskeletal disorders and is able to modulate LPS-induced macrophage production of inflammatory mediators. P2X7R is found on cells of the immune system, e.g., mast cells, microglia, macrophages, T cells, and B cells, in uterine endometrium, retina, and in the central and peripheral nervous systems.
Additional information: Clone REA875 displays negligible binding to Fc receptors.

Alternative names

P2RX7, P2X7

Technical specifications

  • Antigen: P2X7R
  • Clone: REA875
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control antibodies
  • Alternative names of antigen: P2RX7, P2X7
  • Entrez Gene ID: 18439
  • Molecular mass of antigen [kDa]: 68
  • Distribution of antigen: mast cells, microglia, macrophages, B cells, T cells
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, Biotin
  • Selected references

    1. Chessell, I. P. et al. (1998) Cloning and functional characterisation of the mouse P2X7 receptor. FEBS Lett. 439(1-2): 26-30
    2. Kawano, A. et al. (2012) Involvement of P2X4 receptor in P2X7 receptor-dependent cell death of mouse macrophages. Biochem. Biophys. Res. Commun. 419(2): 374-380
    3. Alves, L. A. et al. (2014) The P2X7 receptor: shifting from a low- to a high-conductance channel - an enigmatic phenomenon? Biochim. Biophys. Acta 1838(10): 2578-2587
    4. Bartlett, R. et al. (2014) The P2X7 receptor channel: recent developments and the use of P2X7 antagonists in models of disease. Pharmacol. Rev. 66(3): 638-675
Product options: 8
30 µg in 200 µL (1)
USD 46.00
150 µg in 1 mL (1)
USD 162.00
30 µg in 200 µL (1)
USD 56.00
150 µg in 1 mL (1)
USD 192.00
30 µg in 200 µL (1)
USD 80.00
150 µg in 1 mL (1)
USD 320.00
30 µg in 200 µL (1)
USD 56.00
150 µg in 1 mL (1)
USD 178.00

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