Anti-Melanoma (MCSP) antibodies, human

Anti-Melanoma (MCSP) antibodies, human

Clone: REA1041 | Dilution: 1:50
Clone REA1041 recognizes the melanoma-associated chondroitin sulfate proteoglycan (MCSP) antigen, also known as high molecular weight melanoma-associated antigen. MCSP is expressed on the majority (>90%) of human melanoma tissues and melanoma cell lines but not on carcinoma cells, fibroblastoid cells, and cells of hematopoietic origin.
Additional information: Clone REA1041 displays negligible binding to Fc receptors.

Alternative names

CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2

Technical specifications

  • Antigen: Melanoma (MCSP)
  • Clone: REA1041
  • Isotype: recombinant human IgG1
  • Isotype control: REA Control (S) antibodies
  • Alternative names of antigen: CSPG4, HMW-MAA, MCSP, MCSPG, MEL-CSPG, MSK16, NG2
  • Entrez Gene ID: 1464
  • Molecular mass of antigen [kDa]: 248
  • Distribution of antigen: melanoma
  • Product format: Reagents are supplied in buffer containing stabilizer and 0.05% sodium azide.
  • Fixation: Cells should be stained prior to fixation, if formaldehyde is used as a fixative.
  • Storage: Store protected from light at 2–8 °C. Do not freeze.
  • Available conjugates: FITC, PE, APC, VioBlue, VioGreen, PE-Vio615, PE-Vio770, APC-Vio770, PerCP-Vio700, VioBright 515, Biotin
  • Selected references

    1. Morgan, A. C. et al. (1981) Production and characterization of monoclonal antibody to a melanoma specific glycoprotein. Hybridoma 1: 27-36
    2. Bumol, T. F. and Reisfeld, R. A. (1982) Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells. Proc. Natl. Acad. Sci. U.S.A. 79(4): 1245-1249
    3. Bumol, T. F. et al. (1984) Biosynthetic studies of proteoglycans in human melanoma cells with a monoclonal antibody to a core glycoprotein of chondroitin sulfate proteoglycans. J. Biol. Chem. 259(20): 12733-12741
    4. Pluschke, G. et al. (1996) Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc. Natl. Acad. Sci. U.S.A. 93(18): 9710-9715
    5. Benez, A. et al. (1999) Detection of circulating melanoma cells by immunomagnetic cell sorting. J. Clin. Lab. Anal. 13: 229-233
    6. Siewert, C. et al. (2001) Rapid enrichment and detection of melanoma cells from peripheral blood mononuclear cells by a new assay combining immunomagnetic cell sorting and immunocytochemical staining. Recent Results Cancer Res. 158: 51-60
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